Yes, I’ve had this trouble myself. To be honest it’s a newish technology and I’m pretty sure it still has bugs.
My laptop is a Toshiba with i7 processor with an Intel(R) HD Graphics 4600 and it was this graphics card driver that had the problem. I was moving screen positions around at the time when things started going wobbly.
The fix for me was easy I just went into device manager and removed the Intel display driver and also let it ‘remove’ the files. A reboot later and the problem was solved.
Having said all this I just thought I’d add an additional pointer. After I rebooted I suspect my laptop was displaying the ‘2nd’ screen as primary as there were no desktop icons. This went away when I added a second ‘extended’ display.